Oligohistidine and targeting peptide functionalized TAT-NLS for enhancing cellular uptake and promoting angiogenesis in vivo.

Qian LiXuefang HaoSyed Saqib Ali ZaidiJintang GuoXiangkui RenChangcan ShiWencheng ZhangYakai Feng

Published in: Journal of nanobiotechnology (2018)

The above results indicated that the delivery efficiency of pZNF580 and its expression could be enhanced by introducing Hn sequence into gene carriers. The Hn sequence in REDV-TAT-NLS-Hn is beneficial for high gene transfection. These REDV and Hn functionalized TAT-NLS peptides are promising gene carriers in gene therapy.

Keyphrases

gene therapy
copy number
genome wide
genome wide identification
poor prognosis
quantum dots
amino acid
dna methylation
gene expression
high resolution