IL-2 Combined with IL-15 Enhanced the Expression of NKG2D Receptor on Patient Autologous NK Cells to Inhibit Wilms' Tumor via MAPK Signaling Pathway.
Yanping LiYonglin LiBin XiangXiaomao TianQinlin ShiFeng LiuTao LinGuanghui WeiPublished in: Journal of oncology (2022)
The abnormal NK cell-mediated cytotoxicity may cause the occurrence of WT. Costimulation of WT patients autologous NK cells could effectively enhance the antitumor reaction which involved in activation of NKG2D-mediated MAPK signaling pathway.
Keyphrases
- nk cells
- signaling pathway
- pi k akt
- end stage renal disease
- epithelial mesenchymal transition
- newly diagnosed
- induced apoptosis
- bone marrow
- chronic kidney disease
- poor prognosis
- cell therapy
- oxidative stress
- risk assessment
- cell proliferation
- binding protein
- case report
- long non coding rna
- endoplasmic reticulum stress
- electron transfer