Concentration-dependent effects of dutasteride on prostate-specific membrane antigen (PSMA) expression and uptake of 177 Lu-PSMA-617 in LNCaP cells.
Benedikt KranzbühlerSouzan SalemiChristoph A UmbrichtLuisa M DeberleCristina MüllerIrene A BurgerThomas HermannsTullio SulserDaniel EberliPublished in: The Prostate (2019)
Our investigations revealed a concentration- and time-dependent effect of dutasteride on PSMA expression and uptake of 177Lu -PSMA-617 in LNCaP cells. A short-term treatment of patients with high doses of dutasteride might increase the detection rate of PSMA-based imaging and increase the effect of 177Lu -PSMA-617 therapy via upregulation of PSMA expression.
Keyphrases
- pet ct
- pet imaging
- poor prognosis
- benign prostatic hyperplasia
- induced apoptosis
- positron emission tomography
- prostate cancer
- lower urinary tract symptoms
- cell cycle arrest
- long non coding rna
- binding protein
- stem cells
- cell proliferation
- mesenchymal stem cells
- oxidative stress
- bone marrow
- mass spectrometry
- photodynamic therapy