Epigenetic Regulation of Filaggrin Gene Expression in Human Epidermal Keratinocytes.

Jaehyouk Lee Ara Jang Seong Jun Seo Soon Chul Myung

Published in: Annals of dermatology (2020)

Our in vitro and clinical studies point to this unique CpG site as a potential DNA methylation marker of FLG, which can be a promising therapeutic target in the complications of filaggrin-related skin barrier dysfunction as well as in AD.

Keyphrases

dna methylation
gene expression
wound healing
atopic dermatitis
genome wide
endothelial cells
induced pluripotent stem cells
oxidative stress
soft tissue
pluripotent stem cells
risk factors
climate change
risk assessment