Fibrinolysis as a causative mechanism for bleeding complications on ECMO: a pilot observational prospective study.
Julie HelmsAnaïs CurtiaudFrançois SeveracMarine TschirhartHamid MerdjiMatthieu BourdinGeneviève ContantFrançois DepasseRamy Abou RjeilyLaurent SattlerFerhat MezianiEduardo Angles-CanoPublished in: Anesthesiology (2024)
In patients requiring cardiac and/or pulmonary support with ECMO, D-dimer and tissue plasminogen activator levels were increased with bleeding, findings consistent with fibrinolysis.Although there are multiple causes for fibrinolysis during ECMO, their study suggests that patients who bled had increased contact activation, and may benefit from novel therapeutic agents that inhibit hemostatic activation through this pathway.
Keyphrases
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- end stage renal disease
- respiratory failure
- atrial fibrillation
- newly diagnosed
- ejection fraction
- chronic kidney disease
- pulmonary hypertension
- prognostic factors
- randomized controlled trial
- left ventricular
- risk factors
- clinical trial
- study protocol
- mechanical ventilation
- patient reported outcomes