Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD.

Joshua A WalkerSean RichardsStephen A WhelanSung Bok YooTeresa L RussellNkiruka ArinzeSaran LotfollahzadehMarc A NapoleonMostafa E BelghasemNorman LeeLaura M DemberKatya RavidVipul C Chitalia

Published in: Journal of the American Society of Nephrology : JASN (2021)

Leveraging genetic and pharmacologic manipulation in experimental models and data from human studies implicate IS as an inducer of IDO-1 and a perpetuator of the thrombotic milieu and supports IDO-1 as an antithrombotic target in CKD.

Keyphrases

chronic kidney disease
endothelial cells
pulmonary embolism
electronic health record
atrial fibrillation
induced pluripotent stem cells
genome wide
pluripotent stem cells
big data
copy number
case control
machine learning
deep learning