Spatial proteomics of human diabetic kidney disease, from health to class III.

Ayano KondoMonee McGradyDhiraj NallapothulaHira AliAlexandro E TrevinoAmy LamRyan PreskaH Blaize D'AngioZhenqin WuLauren N LopezHarshanna K BadheshaChenoa R VargasAchyuta RameshNasim WiegleySeung Seok HanMarc Dall'EraKuang-Yu JenAaron T MayerMaryam Afkarian

Published in: Diabetologia (2024)

Using the STEP pipeline, we found alterations in protein expression, cellular phenotypic composition and microenvironment structure with DKD progression, demonstrating the power of this pipeline to reveal the pathophysiology of human DKD.

Keyphrases

endothelial cells
induced pluripotent stem cells
healthcare
public health
type diabetes
stem cells
pluripotent stem cells
mental health
mass spectrometry
gene expression
risk assessment
health information
genome wide
climate change
human health