Autologous peripheral blood stem cell transplantation for relapsed/refractory HIV-associated lymphoma: a phase II clinical study.
Shotaro HagiwaraHirokazu NagaiTomoko UehiraAkiko M SaitoSeiji OkadaPublished in: International journal of hematology (2019)
The outcome of relapsed/refractory HIV-associated lymphoma remains poor, even in the era of combined antiretroviral therapy. However, recent reports showed the efficacy of autologous stem cell transplantation (ASCT). We conducted a single-arm, multicenter phase II study in patients with relapsed/refractory HIV-associated lymphoma to assess the safety and efficacy of ASCT. The study included 14 patients with relapsed/refractory HIV-associated lymphoma. Five patients who achieved partial remission or better after the standard salvage regimen proceeded to ASCT. Conditioning treatment involved ranimustine (300 mg/m2) on day - 6, etoposide (200 mg/m2) on days - 5 to - 3, cytarabine (200 mg/m2) on days - 5 to - 3, and L-PAM (140 mg/m2) on day - 2. All patients achieved engraftment and were alive on day 100 of ASCT. One-year and 2-year overall survival rates were both 40% and 1-year and 2-year progression-free survival rates were both 40%. Grade 2 or 3 diarrhea and oral mucositis were observed in 43% of patients. Cytomegalovirus antigenemia, retinitis, and bacterial infections were noted in 43%, 29%, and 29% of patients, respectively. Therapy-related death was not observed. Although the number of enrolled patients was insufficient for statistical analysis. ASCT was feasible and safe for relapsed/refractory HIV-associated lymphoma.Registration: This study is registered in UMIN-CTR (UMIN000003159).
Keyphrases
- antiretroviral therapy
- end stage renal disease
- stem cell transplantation
- diffuse large b cell lymphoma
- hiv infected
- human immunodeficiency virus
- hiv positive
- acute myeloid leukemia
- chronic kidney disease
- newly diagnosed
- ejection fraction
- acute lymphoblastic leukemia
- hiv aids
- high dose
- clinical trial
- hiv testing
- hepatitis c virus
- peripheral blood
- free survival
- multiple myeloma
- peritoneal dialysis
- prognostic factors
- randomized controlled trial
- emergency department
- phase ii study
- open label
- phase ii
- south africa
- cell therapy
- men who have sex with men
- systemic lupus erythematosus
- epstein barr virus
- patient reported
- double blind
- replacement therapy
- hematopoietic stem cell