Evaluation of 2D and 3D Erythroid Differentiation Protocols Using Sickle Cell Disease and Healthy Donor Induced Pluripotent Stem Cells.
Gabriele Louise Soares MartinsCarolina Kymie Vasques NonakaErik Aranha RossiAdne Vitória Rocha de LimaCorynne Stephanie Ahouefa AdanhoMoisés Santana OliveiraSètondji Cocou Modeste Alexandre YahouédéhouClarissa Lima E Moura de SouzaMarilda de Souza GonçalvesBruno Diaz ParedesBruno Solano de Freitas SouzaPublished in: Cells (2023)
A robust 3D protocol for erythroid differentiation was identified using SCD-iPSCs and comparative analyses; however, the maturation step remains challenging and requires further development.