Intranasal vaccination with an NDV-vectored SARS-CoV-2 vaccine protects against Delta and Omicron challenges.
Bryce M WarnerJacob G E YatesRobert VendramelliThang TruongCourtney MeilleurLily ChanAlexander LeacyPhuc H PhamYanlong PeiLeonardo SustaSarah K WoottonDarwyn KobasaPublished in: NPJ vaccines (2024)
The rapid development and deployment of vaccines following the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been estimated to have saved millions of lives. Despite their immense success, there remains a need for next-generation vaccination approaches for SARS-CoV-2 and future emerging coronaviruses and other respiratory viruses. Here we utilized a Newcastle Disease virus (NDV) vectored vaccine expressing the ancestral SARS-CoV-2 spike protein in a pre-fusion stabilized chimeric conformation (NDV-PFS). When delivered intranasally, NDV-PFS protected both Syrian hamsters and K18 mice against Delta and Omicron SARS-CoV-2 variants of concern. Additionally, intranasal vaccination induced robust, durable protection that was extended to 6 months post-vaccination. Overall, our data provide evidence that NDV-vectored vaccines represent a viable next-generation mucosal vaccination approach.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- disease virus
- type diabetes
- molecular dynamics simulations
- coronavirus disease
- machine learning
- big data
- gene expression
- small molecule
- oxidative stress
- dna methylation
- current status
- high glucose
- bone marrow
- ulcerative colitis
- loop mediated isothermal amplification
- binding protein
- high fat diet induced