Sarah K Wootton

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 49

Top Topics

Pseudomonas Aeruginosa

Gene Expression

Immune Response

Monoclonal Antibody

Top Venues

International journal of molecular sciences

This page only lists publications with an associated author ORCID identifier.

Publications

Jordyn A Lopes, Nicole E Garnier, Yanlong Pei, Jacob G E Yates, Elena S B Campbell, Melanie M Goens, Madison E Hughes, Amira D Rghei, Brenna A Y Stevens, Matthew M Guilleman, Brad Thompson, Cezar M Khursigara, Leonardo Susta, Sarah K Wootton
AAV-vectored expression of monospecific or bispecific monoclonal antibodies protects mice from lethal Pseudomonas aeruginosa pneumonia. Gene therapy 31 (7-8) (2024)
Bryce M Warner, Mable Chan, Nikesh Tailor, Robert Vendramelli, Jonathan Audet, Courtney Meilleur, Thang Truong, Lauren Garnett, Marnie Willman, Geoff Soule, Kevin Tierney, Alixandra Albietz, Estella Moffat, Rick Higgins, Lisa A Santry, Alexander Leacy, Phuc H Pham, Jacob G E Yates, Yanlong Pei, David Safronetz, James E Strong, Leonardo Susta, Carissa Embury-Hyatt, Sarah K Wootton, Darwyn Kobasa
Mucosal Vaccination with a Newcastle Disease Virus-Vectored Vaccine Reduces Viral Loads in SARS-CoV-2-Infected Cynomolgus Macaques. Vaccines 12 (4) (2024)
Jordyn A Lopes, Nicole E Garnier, Yanlong Pei, Jacob G E Yates, Elena S B Campbell, Melanie M Goens, Madison E Hughes, Amira D Rghei, Brenna A Y Stevens, Matthew M Guilleman, Brad Thompson, Cezar M Khursigara, Leonardo Susta, Sarah K Wootton
AAV-vectored expression of monospecific or bispecific monoclonal antibodies protects mice from lethal Pseudomonas aeruginosa pneumonia. Gene therapy (2024)
Bryce M Warner, Mable Chan, Nikesh Tailor, Robert Vendramelli, Jonathan Audet, Courtney Meilleur, Thang Truong, Lauren Garnett, Marnie Willman, Geoff Soule, Kevin Tierney, Alixandra Albietz, Estella Moffat, Rick Higgins, Lisa A Santry, Alexander Leacy, Phuc H Pham, Jacob G E Yates, Yanlong Pei, David Safronetz, James E Strong, Leonardo Susta, Carissa Embury-Hyatt, Sarah K Wootton, Darwyn Kobasa
Mucosal Vaccination with a Newcastle Disease Virus-Vectored Vaccine Reduces Viral Loads in SARS-CoV-2-Infected Cynomolgus Macaques. Vaccines 12 (4) (2024)
Bryce M Warner, Jacob G E Yates, Robert Vendramelli, Thang Truong, Courtney Meilleur, Lily Chan, Alexander Leacy, Phuc H Pham, Yanlong Pei, Leonardo Susta, Sarah K Wootton, Darwyn Kobasa
Intranasal vaccination with an NDV-vectored SARS-CoV-2 vaccine protects against Delta and Omicron challenges. NPJ vaccines 9 (1) (2024)
Bryce M Warner, Jacob G E Yates, Robert Vendramelli, Thang Truong, Courtney Meilleur, Lily Chan, Alexander Leacy, Phuc H Pham, Yanlong Pei, Leonardo Susta, Sarah K Wootton, Darwyn Kobasa
Intranasal vaccination with an NDV-vectored SARS-CoV-2 vaccine protects against Delta and Omicron challenges. NPJ vaccines 9 (1) (2024)
Bryce M Warner, Jacob G E Yates, Robert Vendramelli, Thang Truong, Courtney Meilleur, Lily Chan, Alexander Leacy, Phuc H Pham, Yanlong Pei, Leonardo Susta, Sarah K Wootton, Darwyn Kobasa
Intranasal vaccination with an NDV-vectored SARS-CoV-2 vaccine protects against Delta and Omicron challenges. NPJ vaccines 9 (1) (2024)
Darrick L Yu, Laura P van Lieshout, Brenna A Y Stevens, Kelsie J Jagt Near, Jenny K Stodola, Kevin J Stinson, Durda Slavic, Sarah K Wootton
AAV Vectors Pseudotyped with Capsids from Porcine and Bovine Species Mediate In Vitro and In Vivo Gene Delivery. Viruses 16 (1) (2023)
Darrick L Yu, Laura P van Lieshout, Brenna A Y Stevens, Kelsie J Jagt Near, Jenny K Stodola, Kevin J Stinson, Durda Slavic, Sarah K Wootton
AAV Vectors Pseudotyped with Capsids from Porcine and Bovine Species Mediate In Vitro and In Vivo Gene Delivery. Viruses 16 (1) (2023)
Elena S B Campbell, Melanie M Goens, Wenguang Cao, Brad Thompson, Leonardo Susta, Logan Banadyga, Sarah K Wootton
Recent Advancements in AAV-Vectored Immunoprophylaxis in the Nonhuman Primate Model. Biomedicines 11 (8) (2023)
Amira D Rghei, Jacob G E Yates, Jordyn A Lopes, Xuiaoyan Zhan, Matthew M Guilleman, Yanlong Pei, Laura P van Lieshout, Lisa A Santry, Byram W Bridle, Khalil Karimi, Brad Thompson, Leonardo Susta, James E Crowe, Sarah K Wootton
Antibody-based protection against respiratory syncytial virus in mice and their offspring through vectored immunoprophylaxis. Gene therapy (2023)
Rute Maria Pinto, Siddharth Bakshi, Spyros Lytras, Mohammad Khalid Zakaria, Simon Swingler, Julie C Worrell, Vanessa Herder, Kerrie E Hargrave, Margus Varjak, Natalia Cameron-Ruiz, Mila Collados Rodriguez, Mariana Varela, Arthur Wickenhagen, Colin Loney, Yanlong Pei, Joseph Hughes, Elise Valette, Matthew L Turnbull, Wilhelm Furnon, Quan Gu, Lauren Orr, Aislynn Taggart, Ola Diebold, Christopher A Davis, Chris Boutell, Finn Grey, Edward Hutchinson, Paul Digard, Isabella Monne, Sarah K Wootton, Megan K L MacLeod, Sam J Wilson, Massimo Palmarini
BTN3A3 evasion promotes the zoonotic potential of influenza A viruses. Nature (2023)
Lily Chan, Geoffrey A Wood, Sarah K Wootton, Byram W Bridle, Khalil Karimi
Neutrophils in Dendritic Cell-Based Cancer Vaccination: The Potential Roles of Neutrophil Extracellular Trap Formation. International journal of molecular sciences 24 (2) (2023)
Darrick L Yu, Laura P van Lieshout, Brenna A Y Stevens, Kelsie J Jagt Near, Jenny K Stodola, Kevin J Stinson, Durda Slavic, Sarah K Wootton
AAV Vectors Pseudotyped with Capsids from Porcine and Bovine Species Mediate In Vitro and In Vivo Gene Delivery. Viruses 16 (1) (2023)
Amira D Rghei, Jacob G E Yates, Jordyn A Lopes, Xuiaoyan Zhan, Matthew M Guilleman, Yanlong Pei, Laura P van Lieshout, Lisa A Santry, Byram W Bridle, Khalil Karimi, Brad Thompson, Leonardo Susta, James E Crowe, Sarah K Wootton
Antibody-based protection against respiratory syncytial virus in mice and their offspring through vectored immunoprophylaxis. Gene therapy (2023)
Lily Chan, Geoffrey A Wood, Sarah K Wootton, Byram W Bridle, Khalil Karimi
Neutrophils in Dendritic Cell-Based Cancer Vaccination: The Potential Roles of Neutrophil Extracellular Trap Formation. International journal of molecular sciences 24 (2) (2023)
Darrick L Yu, Laura P van Lieshout, Brenna A Y Stevens, Kelsie J Jagt Near, Jenny K Stodola, Kevin J Stinson, Durda Slavic, Sarah K Wootton
AAV Vectors Pseudotyped with Capsids from Porcine and Bovine Species Mediate In Vitro and In Vivo Gene Delivery. Viruses 16 (1) (2023)
Lily Chan, Geoffrey A Wood, Sarah K Wootton, Byram W Bridle, Khalil Karimi
Neutrophils in Dendritic Cell-Based Cancer Vaccination: The Potential Roles of Neutrophil Extracellular Trap Formation. International journal of molecular sciences 24 (2) (2023)
Lily Chan, Geoffrey A Wood, Sarah K Wootton, Byram W Bridle, Khalil Karimi
Neutrophils in Dendritic Cell-Based Cancer Vaccination: The Potential Roles of Neutrophil Extracellular Trap Formation. International journal of molecular sciences 24 (2) (2023)
Darrick L Yu, Laura P van Lieshout, Brenna A Y Stevens, Kelsie J Jagt Near, Jenny K Stodola, Kevin J Stinson, Durda Slavic, Sarah K Wootton
AAV Vectors Pseudotyped with Capsids from Porcine and Bovine Species Mediate In Vitro and In Vivo Gene Delivery. Viruses 16 (1) (2023)
Nikesh Tailor, Bryce M Warner, Bryan D Griffin, Kevin Tierney, Estella Moffat, Kathy Frost, Robert Vendramelli, Anders Leung, Marnie Willman, Sylvia P Thomas, Yanlong Pei, Stephanie A Booth, Carissa Embury-Hyatt, Sarah K Wootton, Darwyn Kobasa
Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene. Viruses 15 (1) (2022)
Nikesh Tailor, Bryce M Warner, Bryan D Griffin, Kevin Tierney, Estella Moffat, Kathy Frost, Robert Vendramelli, Anders Leung, Marnie Willman, Sylvia P Thomas, Yanlong Pei, Stephanie A Booth, Carissa Embury-Hyatt, Sarah K Wootton, Darwyn Kobasa
Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene. Viruses 15 (1) (2022)
Jordyn A Lopes, Amira D Rghei, Brad Thompson, Leonardo Susta, Cezar M Khursigara, Sarah K Wootton
Overcoming Barriers to Preventing and Treating P. aeruginosa Infections Using AAV Vectored Immunoprophylaxis. Biomedicines 10 (12) (2022)
Elizabeth M Parzych, Jianqiu Du, Ali R Ali, Katherine Schultheis, Drew Frase, Trevor R F Smith, Jiayan Cui, Neethu Chokkalingam, Nicholas J Tursi, Viviane M Andrade, Bryce M Warner, Ebony N Gary, Yue Li, Jihae Choi, Jillian Eisenhauer, Igor Maricic, Abhijeet Kulkarni, Jacqueline D Chu, Gabrielle Villafana, Kim Rosenthal, Kuishu Ren, Joseph R Francica, Sarah K Wootton, Pablo Tebas, Darwyn Kobasa, Kate E Broderick, Jean D Boyer, Mark T Esser, Jesper Pallesen, Daniel W Kulp, Ami Patel, David B Weiner
DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2. Nature communications 13 (1) (2022)
Gina M Cusimano, Ebony N Gary, Matthew R Bell, Bryce M Warner, Jennifer Connors, Nicholas J Tursi, Ali R Ali, Shiyu Zhang, Gabriela Canziani, Bhavani Taramangalam, Emma A Gordon, Irwin M Chaiken, Sarah K Wootton, Trevor Smith, Stephanie J Ramos, Darwyn Kobasa, David B Weiner, Michele A Kutzler, Elias K Haddad
Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1. Journal of immunology (Baltimore, Md. : 1950) 209 (1) (2022)
Ashley A Ross, Lisa A Santry, Matthew M Guilleman, Kathy Matuszewska, Jessica A Minott, Jacob G E Yates, Brenna A Y Stevens, Sylvia P Thomas, Sierra Vanderkamp, Kiersten Hanada, Yanlong Pei, Amira D Rghei, Jacob P van Vloten, Madison Pereira, Brad Thompson, Pierre P Major, James J Petrik, Byram W Bridle, Sarah K Wootton
AAV-Vectored Expression of the Vascular Normalizing Agents 3TSR and Fc3TSR, and the Anti-Angiogenic Bevacizumab Extends Survival in a Murine Model of End-Stage Epithelial Ovarian Carcinoma. Biomedicines 10 (2) (2022)
Amira D Rghei, Laura P van Lieshout, Wenguang Cao, Shihua He, Kevin Tierney, Jordyn A Lopes, Nicole Zielinska, Enzo M Baracuhy, Elena S B Campbell, Jessica A Minott, Matthew M Guilleman, Pamela C Hasson, Brad Thompson, Khalil Karimi, Byram W Bridle, Leonardo Susta, Xiangguo Qiu, Logan Banadyga, Sarah K Wootton
Adeno-associated virus mediated expression of monoclonal antibody MR191 protects mice against Marburg virus and provides long-term expression in sheep. Gene therapy (2022)
Nikesh Tailor, Bryce M Warner, Bryan D Griffin, Kevin Tierney, Estella Moffat, Kathy Frost, Robert Vendramelli, Anders Leung, Marnie Willman, Sylvia P Thomas, Yanlong Pei, Stephanie A Booth, Carissa Embury-Hyatt, Sarah K Wootton, Darwyn Kobasa
Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene. Viruses 15 (1) (2022)
Jacob P van Vloten, Kathy Matuszewska, Mark A A Minow, Jessica A Minott, Lisa A Santry, Madison Pereira, Ashley A Stegelmeier, Thomas M McAusland, Elaine M Klafuric, Khalil Karimi, Joseph Colasanti, D Grant McFadden, James J Petrik, Byram W Bridle, Sarah K Wootton
Oncolytic Orf virus licenses NK cells via cDC1 to activate innate and adaptive antitumor mechanisms and extends survival in a murine model of late-stage ovarian cancer. Journal for immunotherapy of cancer 10 (3) (2022)
Nikesh Tailor, Bryce M Warner, Bryan D Griffin, Kevin Tierney, Estella Moffat, Kathy Frost, Robert Vendramelli, Anders Leung, Marnie Willman, Sylvia P Thomas, Yanlong Pei, Stephanie A Booth, Carissa Embury-Hyatt, Sarah K Wootton, Darwyn Kobasa
Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene. Viruses 15 (1) (2022)
Jordyn A Lopes, Amira D Rghei, Brad Thompson, Leonardo Susta, Cezar M Khursigara, Sarah K Wootton
Overcoming Barriers to Preventing and Treating P. aeruginosa Infections Using AAV Vectored Immunoprophylaxis. Biomedicines 10 (12) (2022)
Nikesh Tailor, Bryce M Warner, Bryan D Griffin, Kevin Tierney, Estella Moffat, Kathy Frost, Robert Vendramelli, Anders Leung, Marnie Willman, Sylvia P Thomas, Yanlong Pei, Stephanie A Booth, Carissa Embury-Hyatt, Sarah K Wootton, Darwyn Kobasa
Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene. Viruses 15 (1) (2022)
Robert C Mould, Jacob P van Vloten, Amanda W K AuYeung, Scott R Walsh, Jondavid de Jong, Leonardo Susta, Anthony J Mutsaers, James J Petrik, Geoffrey A Wood, Sarah K Wootton, Khalil Karimi, Byram W Bridle
Using a Prime-Boost Vaccination Strategy That Proved Effective for High Resolution Epitope Mapping to Characterize the Elusive Immunogenicity of Survivin. Cancers 13 (24) (2021)
Amira D Rghei, Laura P van Lieshout, Benjamin M McLeod, Yanlong Pei, Jordyn A Lopes, Nicole Zielinska, Enzo M Baracuhy, Brenna A Y Stevens, Sylvia P Thomas, Jacob G E Yates, Bryce M Warner, Darwyn Kobasa, Hugues Fausther-Bovendo, Gary P Kobinger, Khalil Karimi, Brad Thompson, Byram W Bridle, Leonardo Susta, Sarah K Wootton
Safety and Tolerability of the Adeno-Associated Virus Vector, AAV6.2FF, Expressing a Monoclonal Antibody in Murine and Ovine Animal Models. Biomedicines 9 (9) (2021)
Ashley A Ross, Maedeh Darzianiazizi, Kiersten Hanada, Shayan Sharif, Sarah K Wootton, Byram W Bridle, Khalil Karimi
Type I Interferon-Mediated Regulation of Antiviral Capabilities of Neutrophils. International journal of molecular sciences 22 (9) (2021)
Julia Puppin Chaves Fulber, Omar Farnós, Sascha Kiesslich, Zeyu Yang, Shantoshini Dash, Leonardo Susta, Sarah K Wootton, Amine A Kamen
Process Development for Newcastle Disease Virus-Vectored Vaccines in Serum-Free Vero Cell Suspension Cultures. Vaccines 9 (11) (2021)
Matthew M Guilleman, Brenna A Y Stevens, Laura P Van Lieshout, Amira D Rghei, Yanlong Pei, Lisa A Santry, Brad Thompson, Sarah K Wootton
AAV-mediated delivery of actoxumab and bezlotoxumab results in serum and mucosal antibody concentrations that provide protection from C. difficile toxin challenge. Gene therapy (2021)
Darrick L Yu, Natalie S M Chow, Byram W Bridle, Sarah K Wootton
Macrophage Depletion via Clodronate Pretreatment Reduces Transgene Expression from AAV Vectors In Vivo. Viruses 13 (10) (2021)
Martin H Kang, Laura P van Lieshout, Liqun Xu, Jakob M Domm, Arul Vadivel, Laurent Renesme, Christian Mühlfeld, Maria Hurskainen, Ivana Mižíková, Yanlong Pei, Jacob P van Vloten, Sylvia P Thomas, Claudia Milazzo, Chanèle Cyr-Depauw, Jeffrey A Whitsett, Lawrence M Nogee, Sarah K Wootton, Bernard Thébaud
A lung tropic AAV vector improves survival in a mouse model of surfactant B deficiency. Nature communications 11 (1) (2020)
Ashley A Ross, Lily Chan, Yeganeh Mehrani, James J Petrik, Sarah K Wootton, Byram W Bridle, Khalil Karimi
Characterization of the Impact of Oncolytic Vesicular Stomatitis Virus on the Trafficking, Phenotype, and Antigen Presentation Potential of Neutrophils and Their Ability to Acquire a Non-Structural Viral Protein. International journal of molecular sciences 21 (17) (2020)
Laura P van Lieshout, Ashley A Stegelmeier, Tara N Rindler, John J Lawder, Debra L Sorensen, Kathy L Frost, Stephanie A Booth, James P Bridges, Sarah K Wootton
Engineered AAV8 capsid acquires heparin and AVB sepharose binding capacity but has altered in vivo transduction efficiency. Gene therapy (2020)
Darrick L Yu, Natalie S M Chow, Sarah K Wootton
JSRV Intragenic Enhancer Element Increases Expression from a Heterologous Promoter and Promotes High Level AAV-mediated Transgene Expression in the Lung and Liver of Mice. Viruses 12 (11) (2020)
Amira D Rghei, Laura P van Lieshout, Lisa A Santry, Matthew M Guilleman, Sylvia P Thomas, Leonardo Susta, Khalil Karimi, Byram W Bridle, Sarah K Wootton
AAV Vectored Immunoprophylaxis for Filovirus Infections. Tropical medicine and infectious disease 5 (4) (2020)
Lisa A Santry, Renaud Jacquemart, Melissa Vandersluis, Mochao Zhao, Jake M Domm, Thomas M McAusland, Xiaojiao Shang, Pierre M Major, James G Stout, Sarah K Wootton
Interference chromatography: a novel approach to optimizing chromatographic selectivity and separation performance for virus purification. BMC biotechnology 20 (1) (2020)
Ashley A Ross, Jacob P van Vloten, Robert C Mould, Elaine M Klafuric, Jessica A Minott, Sarah K Wootton, Byram W Bridle, Khalil Karimi
Myeloid Cells during Viral Infections and Inflammation. Viruses 11 (2) (2019)
Darrick L Yu, Ashley A Ross, Natalie Chow, Amira D Rghei, Kathy Matuszewska, Jack Lawler, Byram W Bridle, James J Petrik, Sarah K Wootton
AAV-mediated expression of 3TSR inhibits tumor and metastatic lesion development and extends survival in a murine model of epithelial ovarian carcinoma. Cancer gene therapy 27 (5) (2019)
Jegarubee Bavananthasivam, Leah Read, Jake Astill, Alexander Yitbarek, Tamiru N Alkie, Mohamed Faizal Abdul-Careem, Sarah K Wootton, Shahriar Behboudi, Shayan Sharif
The effects of in ovo administration of encapsulated Toll-like receptor 21 ligand as an adjuvant with Marek's disease vaccine. Scientific reports 8 (1) (2018)
Jacob P van Vloten, Samuel Tekeste Workenhe, Sarah K Wootton, Karen L Mossman, Byram W Bridle
Critical Interactions between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies. Journal of immunology (Baltimore, Md. : 1950) 200 (2) (2018)
Robert C Mould, Amanda W K AuYeung, Jacob P van Vloten, Leonardo Susta, Anthony J Mutsaers, James J Petrik, Geoffrey A Wood, Sarah K Wootton, Khalil Karimi, Byram W Bridle
Enhancing Immune Responses to Cancer Vaccines Using Multi-Site Injections. Scientific reports 7 (1) (2017)