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pH-Dependent Protonation of Histidine Residues Is Critical for Electrostatic Binding of Low-Density Lipoproteins to Human Coronary Arteries.

Lars GliseMikael RutbergLiliana HåversenMalin C LevinMax LevinAnders JeppssonJan BorénPer Fogelstrand
Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)
This study identifies histidine protonation as an important component for electrostatic LDL binding to human coronary arteries. Our findings show that the local pH will have a profound impact on LDL's affinity for sulfated glycosaminoglycans, which may influence the retention and accumulation pattern of LDL in the arterial vasculature.
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