Association of Pulmonary Hemorrhage, Positive Proteinase 3, and Urinary Red Blood Cell Casts With Venous Thromboembolism in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Andreas KronbichlerJohannes LeiererJae Il ShinPeter A MerkelRobert SpieraPhilip SeoCarol A LangfordGary S HoffmanCees G M KallenbergE William St ClairPaul BrunettaFernando C FervenzaDuvuru GeethaKarina A KeoghPaul A MonachSteven R YtterbergGert MayerUlrich SpecksJohn H Stonenull nullPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
Patients diagnosed as having AAV with pulmonary hemorrhage, positive PR3-ANCA, heart involvement, and the presence of red blood cell casts are at an increased risk to develop VTE. Further studies are needed to confirm and expand these findings and to explore the mechanisms of hypercoagulability in these patients with the aim of informing potential targets for therapeutic intervention.