[Intrathecal chemotherapy for leptomeningeal metastases in patients with breast cancer].
E A MoskvinaA Kh BekyashevD R NaskhletashviliL V MekhedaV A AleshinT G GasparyanA A MitrofanovN V SevyanE V ProzorenkoA A TkhazeplovK E RoshchinaPublished in: Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko (2024)
Effectiveness of ITT is confirmed by higher quality of life (72% of patients), complete cytological responses (24%) and improvement in neuroimaging data. This is an important criterion for severe patients with limited treatment options. First-stage ITT before whole-brain irradiation is preferable, as this approach increases overall survival by 3 months. Undoubtedly, ITT is a treatment option that can be used in routine clinical practice for lesions of brain and spinal cord sheaths.
Keyphrases
- clinical practice
- spinal cord
- end stage renal disease
- resting state
- white matter
- chronic kidney disease
- randomized controlled trial
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- prognostic factors
- electronic health record
- spinal cord injury
- functional connectivity
- locally advanced
- small cell lung cancer
- squamous cell carcinoma
- multiple sclerosis
- early onset
- patient reported outcomes
- machine learning
- cerebrospinal fluid
- rectal cancer
- radiation induced
- artificial intelligence
- subarachnoid hemorrhage
- brain injury
- ultrasound guided