Levothyroxine for subclinical hypothyroidism during pregnancy: an updated systematic review and meta-analysis of randomized controlled trials.

Henrique ProvinciattoMarcus Vinicius Barbosa MoreiraGabriel Rezende NevesLucas Rezende De FreitasHenrique Costa MitsuiJulio Min Fei ZhangAntonio Fernandes Moron

Published in: Archives of gynecology and obstetrics (2024)

Levothyroxine replacement therapy for subclinical hypothyroidism during pregnancy may decrease pregnancy loss when early prescribed. Nevertheless, further investigation is needed in patients with thyroid stimulating hormone above four milliunits per liter, especially when associated with recurrent miscarriage or infertility.

Keyphrases

systematic review
replacement therapy
meta analyses
preterm birth
pregnancy outcomes
randomized controlled trial
polycystic ovary syndrome
pregnant women
insulin resistance