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Gemcitabine and vinorelbine treatment in cutaneous T-cell lymphoma in four patients.

Azura Mohd AffandiTatiana Pinto BlumettiJillian WellsMark HertzbergPablo Fernandez-Penas
Published in: The Australasian journal of dermatology (2014)
Treatment options for advanced stage cutaneous T-cell lymphoma (CTCL) are limited by the their efficacy and side-effects profile. Gemcitabine, a pyrimidine analogue, has been reported to be efficacious in CTCL. Most of the studies published used gemcitabine as a single agent in treating advanced CTCL. Our small case series demonstrated that a combination of gemcitabine and vinorelbine induced partial remission in all four patients with refractory or advanced CTCL, although the effects were not sustained for a long duration (2-6 months). Two patients had neutropenia and one had acute hepatitis, requiring discontinuation of treatment.
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