Up-regulation of PYK2/PKCα-dependent haem oxygenase-1 by CO-releasing molecule-2 attenuates TNF-α-induced lung inflammation.

Chih-Chung LinYu-Ching ChiangRou-Ling ChoWei-Ning LinChien-Chung YangLi-Der HsiaoChuen-Mao Yang

Published in: British journal of pharmacology (2017)

CORM-2 activates a PYK2/PKCα/ERK1/2/AP-1 pathway leading to HO-1 expression in HPAEpiCs. This HO-1/CO system might have potential as a therapeutic target in pulmonary inflammation.

Keyphrases

oxidative stress
pi k akt
diabetic rats
poor prognosis
signaling pathway
rheumatoid arthritis
high glucose
pulmonary hypertension
cell proliferation
transcription factor
binding protein
risk assessment
endothelial cells
long non coding rna
human health
climate change