Transcriptomic Profiling Identifies Ferroptosis-Related Gene Signatures in Ischemic Muscle Satellite Cells Affected by Peripheral Artery Disease.
Lillian TranBowen XieEdwyn AssafRicardo FerrariIraklis I PipinosGeorge P CasaleRoberto Ivan Mota AlvidrezSimon C WatkinsUlka SachdevPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
This is the first report documenting that genes known to be involved in ferroptosis are differentially expressed in human skeletal muscle affected by PAD. Targeting ferroptosis may be a novel therapeutic strategy to reduce PAD myopathy.
Keyphrases
- genome wide
- cell death
- skeletal muscle
- cell cycle arrest
- peripheral artery disease
- dna methylation
- induced apoptosis
- single cell
- endothelial cells
- genome wide identification
- copy number
- insulin resistance
- late onset
- induced pluripotent stem cells
- rna seq
- pluripotent stem cells
- cancer therapy
- genome wide analysis
- ischemia reperfusion injury
- gene expression
- type diabetes
- oxidative stress
- adipose tissue
- transcription factor
- drug delivery
- early onset