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Studying human immunodeficiencies in humans: advances in fundamental concepts and therapeutic interventions.

Helen C Su
Published in: F1000Research (2017)
Immunodeficiencies reveal the crucial role of the immune system in defending the body against microbial pathogens. Given advances in genomics and other technologies, this is currently best studied in humans who have inherited monogenic diseases. Such investigations have provided insights into how gene products normally function in the natural environment and have opened the door to new, exciting treatments for these diseases.
Keyphrases
  • genome wide
  • endothelial cells
  • single cell
  • microbial community
  • physical activity
  • copy number
  • induced pluripotent stem cells
  • pluripotent stem cells
  • gram negative
  • dna methylation