Sbk2, a Newly Discovered Atrium-Enriched Regulator of Sarcomere Integrity.
Pim R R van GorpJuan ZhangJia LiuRoula TsonakaHailiang MeiSven O DekkerCindy I BartTim De CosterHarm PostAlbert J R HeckMartin J SchalijDouwe E AtsmaDaniel A PijnappelsAntoine A F de VriesPublished in: Circulation research (2022)
iAM-1 cells are a relevant and suitable model to identify (lowly expressed) genes with a hitherto unidentified role in cardiomyocyte differentiation as exemplified by Sbk2: a regulator of atrial sarcomerogenesis.
Keyphrases
- induced apoptosis
- transcription factor
- cell cycle arrest
- atrial fibrillation
- genome wide
- pulmonary artery
- catheter ablation
- endoplasmic reticulum stress
- vena cava
- signaling pathway
- angiotensin ii
- oxidative stress
- left atrial
- cell death
- heart failure
- coronary artery
- left atrial appendage
- cell proliferation
- endothelial cells
- pulmonary arterial hypertension