Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics.

Samrat Roy ChoudhuryStephanie D ByrumDuah AlkamCody AshbyFenghuang ZhanAlan J TackettFrits Van Rhee

Published in: Clinical epigenetics (2023)

Our findings suggest an epigenetic regulation of oncogenic overexpression of ITGB7 in MM cells, which could be critical in MM progression and an attractive therapeutic target.

Keyphrases

multiple myeloma
induced apoptosis
poor prognosis
transcription factor
cell cycle arrest
cell proliferation
oxidative stress
signaling pathway