MD2 Blockage Protects Obesity-Induced Vascular Remodeling via Activating AMPK/Nrf2.
Lintao WangJibo HanPeiren ShanShengban YouXuemei ChenYiyi JinJingying WangWeijian HuangYi WangGuang LiangPublished in: Obesity (Silver Spring, Md.) (2017)
It was demonstrated that the deletion or inhibition of MD2 protects against HFD/FFA-induced vascular oxidative stress and remodeling by activating the AMPK/Nrf2-signaling pathway.
Keyphrases
- oxidative stress
- signaling pathway
- diabetic rats
- high glucose
- induced apoptosis
- molecular dynamics
- metabolic syndrome
- skeletal muscle
- type diabetes
- weight loss
- drug induced
- epithelial mesenchymal transition
- high fat diet
- protein kinase
- ischemia reperfusion injury
- weight gain
- high fat diet induced
- body mass index
- endoplasmic reticulum stress
- heat shock protein