Expression of immune checkpoint receptors Indoleamine 2,3-dioxygenase and T cell Ig and ITIM domain in metastatic versus nonmetastatic choroidal melanoma.

Gustav StålhammarStefan SeregardHans E Grossniklaus

Published in: Cancer medicine (2019)

The expression of immune checkpoint receptor TIGIT is increased in primary uveal melanomas that seed metastases, and correlates with the expression of checkpoint receptor IDO. Both may be future targets for therapy.

Keyphrases

poor prognosis
binding protein
squamous cell carcinoma
small cell lung cancer
dna damage
stem cells
optical coherence tomography
mesenchymal stem cells
oxidative stress
replacement therapy