Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.
Amy E AdkinsLaura M HackTim B BigdeliVernell S WilliamsonG Omari McMichaelMohammed MamdaniAlexis C EdwardsFazil AlievRobin F ChanPoonam BhandariRichard C RaabeJoseph T AlaimoGinaMari G BlackwellArden MoscatiRyan S PolandBenjamin RoodDiana G PattersonDermot Walshnull nullJohn B WhitfieldGu ZhuGrant W MontgomeryAnjali K HendersNicholas G MartinAndrew C HeathPamela A F MaddenJosef FrankMonika RidingerNorbert WodarzMichael SoykaPeter ZillMarcus IsingMarkus M NöthenFalk KieferMarcella Rietschelnull nullJoel GelernterRichard ShervaRyan KoestererLaura AlmasyHongyu ZhaoHenry R KranzlerLindsay A FarrerBrion S MaherCarol A PrescottDanielle M DickSilviu A BacanuLaura D MathiesAndrew G DaviesVladimir I VladimirovMike GrotewielM Scott BowersJill C BettingerBradley T WebbMichael F MilesKenneth S KendlerBrien P RileyPublished in: Alcoholism, clinical and experimental research (2017)
We detect association between AD and COL6A3, KLF12, RYR3, and LOC339975. Despite nonreplication of COL6A3, KLF12, and RYR3 signals, orthologs of these genes influence behavioral response to EtOH in MOs, suggesting potential involvement in human EtOH response and AD liability. The associated LOC339975 allele may influence gene expression in human NAc. Although the functions of long noncoding RNAs are poorly understood, there is mounting evidence implicating these genes in multiple brain functions and disorders.