TMEM27 expression and clinical characteristics and survival in clear cell renal cell carcinoma.
Rickinder GrewalHae Yoon Grace ChoungLisa L RobertsTimothy BeaneLuojing ChenDaniel X GilroyPhillip M RappoldThu H LePublished in: Acta oncologica (Stockholm, Sweden) (2022)
The absence of TMEM27 expression is associated with more aggressive tumor characteristics and poorer all-cause mortality and disease-free survival in ccRCC. TMEM27 may be a useful biomarker to assess cancer prognosis. Further studies are needed to better assess if TMEM27 is protective in RCC, and its potential role in active surveillance and prediction of response to target therapy.