Management of bone metastasis with intravenous bisphosphonates in breast cancer: a systematic review and meta-analysis of dosing frequency.

Mei YangXijie Yu

Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2020)

This analysis suggested that de-escalation treatment with bisphosphates may be superior to standard treatment in terms of efficacy, safety, and economic costs. But it would be better that all the patients receive bisphosphates every 4 weeks for several months before de-escalation.

Keyphrases

end stage renal disease
open label
randomized controlled trial
peritoneal dialysis
prognostic factors
bone mineral density
young adults
replacement therapy
postmenopausal women
study protocol
patient reported