Lancemaside A from Codonopsis lanceolata prevents hypertension by inhibiting NADPH oxidase 2-mediated MAPK signalling and improving NO bioavailability in rats.

You Kyoung ShinA Young HanYu Shan HsiehSoonho KwonJinhye KimKwang-Won Lee Geun Hee Seol

Published in: The Journal of pharmacy and pharmacology (2019)

Lancemaside A prevents hypertension in rats by inhibiting the activation of MAPK signalling and the impairment in nitric oxide bioavailability due to NOX2-mediated oxidative stress. Thus, LMA may act as a preventive agent for hypertension.

Keyphrases

blood pressure
signaling pathway
oxidative stress
nitric oxide
pi k akt
induced apoptosis
dna damage
mouse model
ischemia reperfusion injury
arterial hypertension
heat stress