ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress.
Xiaoding WangGuangyu ZhangSubhajit DasguptaErica L NiewoldChao LiQinfeng LiXiang LuoLin TanAnwarul FerdousPhilip L LorenziBeverly A RothermelThomas G GilletteChristopher M AdamsPhilipp E SchererJoseph A HillZhao V WangPublished in: Circulation research (2022)
Our findings reveal that ATF4 plays a critical role in the heart under conditions of hemodynamic stress by governing both cytosolic and mitochondrial production of NADPH.