Pooling individual participant data from randomized controlled trials: Exploring potential loss of information.

Lennard L van WanrooijMarieke P Hoevenaar-BlomNicola ColeyTiia NganduYannick MeillerJuliette GuillemontAnna RosenbergCathrien R L BeishuizenEric P Moll van CharanteHilkka SoininenCarol BrayneSandrine AndrieuMiia KivipeltoEdo Richard

Published in: PloS one (2020)

Large, pooled datasets provide great opportunities, justifying the efforts for data harmonization. Still, caution is warranted when using recoded variables which variance is explained limitedly by their original variables as this may jeopardize the validity of study results.

Keyphrases

electronic health record
randomized controlled trial
big data
data analysis
clinical trial
human health
rna seq
study protocol
climate change
open label