Training program-induced skeletal muscle adaptations in two men with myotonic dystrophy type 1.
Marie-Pier RousselMarika MorinMélina GirardinAnne-Marie FortinMario LeoneJean MathieuCynthia GagnonElise DuchesnePublished in: BMC research notes (2019)
Muscular adaptations occurred only in Patient 1, who attended 72% of the training sessions compared to 39% for Patient 2. These adaptations included increase in the CSA of type I and II myofibers and changes in their proportion. No changes were observed in the percentage of CNF, infiltration of neutrophils and macrophages and muscle strength. These results illustrate the capacity of skeletal muscle cells to undergo adaptations linked to muscle growth in DM1 patients. Also, these adaptations seem to be dependent on the attendance. Trial registration Clinicaltrials.gov NCT04001920 retrospectively registered on June 26th, 2019.
Keyphrases
- skeletal muscle
- high intensity
- insulin resistance
- end stage renal disease
- case report
- newly diagnosed
- induced apoptosis
- ejection fraction
- resistance training
- chronic kidney disease
- study protocol
- prognostic factors
- randomized controlled trial
- metabolic syndrome
- clinical trial
- oxidative stress
- early onset
- diabetic rats
- open label
- pi k akt