Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data.
Seymour M LopezLeon M AksmanNeil P OxtobySjoerd B VosJun RaoErik KaestnerSaud AlhusainiMarina K M AlvimBenjamin BenderAndrea BernasconiNeda BernasconiBoris C BernhardtLeonardo BonilhaLorenzo CaciagliBenoit CaldairouMaria Eugenia CaligiuriAngels CalvetFernando CendesLuis ConchaEstefania Conde-BlancoEsmaeil Davoodi-BojdChristophe E de BézenacNorman DelantyPatricia M DesmondOrrin DevinskyMartin DominJohn S DuncanNiels K FockeSonya FoleyFrancesco FortunatoMarian GalovicAntonio GambardellaEzequiel L GleichgerrchtRenzo GuerriniKhalid HamandiVictoria Ives-DeliperiGraeme D JacksonNeda JahanshadSimon S KellerPeter KochunovRaviteja KotikalapudiBarbara A K KreilkampAngelo LabateSara LariviereMatteo LengeElaine LuiCharles B MalpasPascal MartinMario MascalchiSarah E MedlandStefano MelettiMárcia E MoritaThomas W OwenMark RichardsonAntonella RivaTheodor RuberBenjamin SinclairHamid Soltanian-ZadehDan J SteinPasquale StrianoPeter Neal TaylorSophia I ThomopoulosPaul M ThompsonManuela TondelliAnna Elisabetta VaudanoLucy E VivashYujiang WangBernd WeberChristopher D WhelanRoland WiestGavin P WinstonClarissa Lin YasudaCarrie R McDonaldDaniel C AlexanderSanjay M SisodiyaAndré Altmannnull nullPublished in: Epilepsia (2022)
From cross-sectional MRI, we reconstructed a disease progression model that highlights a sequence of MRI changes that aligns with previous longitudinal studies. This model could be used to stage MTLE-HS subjects in other cohorts and help establish connections between imaging-based progression staging and clinical features.