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HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases.

Anna CalliariLillian M DaughrityEllen A AlbagliPaula Castellanos OteroMei YueKaren Jansen-WestNaeyma N IslamThomas CaulfieldBailey RawlinsonMichael DeTureCasey CookNeill R Graff-RadfordGregory S DayBradley F BoeveDavid S KnopmanRonald C PetersenKeith A JosephsBjörn OskarssonAaron D GitlerDennis W DicksonTania F GendronMercedes PrudencioMichael E WardYong-Jie ZhangLeonard Petrucelli
Published in: Molecular neurodegeneration (2024)
This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.
Keyphrases
  • risk assessment
  • human health
  • amyotrophic lateral sclerosis
  • binding protein
  • circulating tumor
  • oxidative stress
  • cell free
  • single molecule