N6-methyladenosine demethylase fat mass and obesity-associated protein suppresses hyperglycemia-induced endothelial cell injury by inhibiting reactive oxygen species formation via autophagy promotion.
Di XieKelaier YangYang XuYang LiChunnan LiuYanghong DongJinyu ChiXinhua YinPublished in: Journal of diabetes and its complications (2024)
Our study demonstrates the functional importance of FTO-mediated m6A modification in alleviating endothelial cell injury under high glucose conditions and indicates that FTO may be a novel therapeutic target for diabetic vascular complications.
Keyphrases
- high glucose
- endothelial cells
- signaling pathway
- reactive oxygen species
- type diabetes
- metabolic syndrome
- insulin resistance
- cell death
- adipose tissue
- vascular endothelial growth factor
- weight loss
- endoplasmic reticulum stress
- oxidative stress
- diabetic rats
- risk factors
- wound healing
- fatty acid
- high fat diet induced
- physical activity
- skeletal muscle