Evaluation of the Antihemostatic and Antithrombotic Effects of Lowering Coagulation Factor VII Levels in a Non-human Primate.
Michael WallischSven R OlsonJeffrey CrosbyJennifer JohnsonSusan F MurrayJoseph J ShatzelErik I TuckerOwen J T McCartyMonica T HindsBrett P MoniaAndrás GruberPublished in: Cellular and molecular bioengineering (2020)
FVII inhibition by way of ASO is feasible yet significantly impairs hemostasis while only exhibiting antithrombotic effects when thrombosis is initiated by vessel wall surface-associated TF exposure.