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The role of miRNA-128 in the development and progression of gastrointestinal and urogenital cancer.

Ghaidaa Raheem Lateef Al-AwsiSaade Abdalkareem JasimYasser Fakri MustafaFiras Rahi AlhachamiShukhrat ZiyadullaevMahmoud KandeelRoua AbulkassimR SivaramanNoora M HameedRosario Mireya Romero ParraSajad KarampoorRasoul Mirzaei
Published in: Future oncology (London, England) (2022)
Increasing data have shown the significance of various miRNAs in malignancy. In this regard, parallel to its biological role in normal tissues, miRNA-128 (miR-128) has been found to play an essential immunomodulatory function in the process of cancer initiation and development. The occurrence of the aberrant expression of miR-128 in tumors and the unique properties of miRNAs raise the prospect of their use as biomarkers and the next generation of molecular anticancer therapies. The function of miR-128 in malignancies such as breast, prostate, colorectal, gastric, pancreatic, esophageal, cervical, ovarian and bladder cancers and hepatocellular carcinoma is discussed in this review. Finally, the effect of exosomal miR-128 on cancer resistance to therapeutics and cancer immunotherapy in certain malignancies is highlighted.
Keyphrases
  • cell proliferation
  • long non coding rna
  • papillary thyroid
  • long noncoding rna
  • squamous cell
  • poor prognosis
  • prostate cancer
  • gene expression
  • spinal cord injury
  • small molecule
  • machine learning
  • big data
  • current status