Sleeve Gastrectomy Improves High-Fat Diet-Associated Hepatic Steatosis Independent of the Glucagon-like-Petpide-1 Receptor in Rats.

Matthew BarronHailey HayesDeemantha G FernandoAron M GeurtsTammy Lyn Kindel

Published in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (2022)

Loss of the GLP-1R in rats resulted in increased adiposity, insulin resistance, and severe steatosis. A functional GLP-1R is not critical to the metabolic efficacy of SG in Lewis rats, similar to mouse studies, but importantly including steatosis, supporting a GLP-1R-independent mechanism for the improvement in fatty liver disease after SG.

Keyphrases

insulin resistance
high fat diet
adipose tissue
metabolic syndrome
skeletal muscle
polycystic ovary syndrome
high fat diet induced
type diabetes
early onset
body mass index
physical activity
fatty acid
binding protein