Human liver single nucleus and single cell RNA sequencing identify a hepatocellular carcinoma-associated cell-type affecting survival.

Marcus AlvarezJihane N BenhammouNicholas Darci-MaherSamuel W FrenchSteven B HanJanet S SinsheimerVatche G AgopianJoseph R PisegnaPäivi Pajukanta

Published in: Genome medicine (2022)

By integrating liver single cell, single nucleus, and bulk expression data from multiple cohorts we identified a proliferating cell-type (Prol) enriched in HCC tumors, associated with a decreased overall survival, and linked to TP53 and RB1 somatic mutations.

Keyphrases

single cell
rna seq
high throughput
poor prognosis
electronic health record
big data
machine learning
gene expression
artificial intelligence
genome wide
long non coding rna