Transcriptome profiles of the skeletal muscle of mature cows during feed restriction and realimentation.
Hannah C Cunningham-HollingerLarry A KuehnKristi M CammackKristin E HalesWilliam T OliverMatthew S CrouseCeline ChenHarvey C FreetlyAmanda K Lindholm-PerryPublished in: BMC research notes (2021)
A total of 567 differentially expressed genes (408 up- and 159 down-regulated) were identified for the comparison of restriction and ad libitum periods (PBonferroni < 0.05). These genes were over-represented in lysosome, aminoacyl-tRNA biosynthesis, and glutathione metabolism pathways. Validation of the expression of five of the genes was performed and four were confirmed. These data suggest that realimentation weight gain for all cows is partially controlled by protein turnover, but oxidative stress and cellular signaling pathways are also involved in the muscle tissue. This dataset provides insight into molecular mechanisms utilized by mature cows during realimentation after a period of low abundance feed.
Keyphrases
- weight gain
- skeletal muscle
- genome wide
- oxidative stress
- body mass index
- bioinformatics analysis
- genome wide identification
- birth weight
- poor prognosis
- signaling pathway
- dna methylation
- transcription factor
- gene expression
- electronic health record
- insulin resistance
- machine learning
- induced apoptosis
- big data
- epithelial mesenchymal transition
- cell proliferation
- small molecule
- adipose tissue
- fluorescent probe
- ischemia reperfusion injury
- living cells
- endoplasmic reticulum stress
- amino acid
- pi k akt
- cell wall
- diabetic rats
- wastewater treatment
- heat shock protein
- long non coding rna
- deep learning