Cytokines, 25-OH vit D and disease activity in patients with juvenile-onset systemic lupus erythematosus.

IFN-γ and IL-17 were significantly higher in JO-SLE patients, while 25-OH Vit D was significantly lower compared to controls. There was a negative correlation between 25-OH Vit D and each of SLEDAI-2K and IFN-γ.