After JAK inhibitor failure: to cycle or to switch, that is the question - data from the JAK-pot collaboration of registries.

Manuel Pombo-SuarezCarlos Sanchez-PiedraJuan Gómez-ReinoKim LauperDenis MonginFlorenzo IannoneKarel PavelkaDan C NordströmGüzide Nevsun İnançCatalin CodreanuKimmie L HyrichDenis ChoquetteAnja StrangfeldBurkhard F LeebZiga RotarAna RodriguesEirik Klami KristianslundTore K KvienOri ElkayamGalina LukinaSytske Anne Bergstra Axel Finckh Delphine Sophie Courvoisier

Published in: Annals of the rheumatic diseases (2022)

After failing the first JAKi, cycling JAKi and switching to a bDMARD appear to have similar effectiveness. Caution is advised if an AE was the reason to stop the first JAKi.

Keyphrases

randomized controlled trial
systematic review
electronic health record
high intensity
big data
machine learning
artificial intelligence