Visible-Light-Promoted Cross-Coupling of O -Aryl Oximes and Nitrostyrenes to Access Cyanoalkylated Alkenes.

Jie GaoZhi-Peng YeYu-Fei LiuXian-Chen HeJian-Ping GuanFang LiuKai Chen Hao-Yue Xiang Xiao-Qing Chen Jun-An Xiao

Published in: Organic letters (2022)

A photoinduced, photocatalyst-free cyanoalkylation of nitrostyenes was explored, affording a series of cyanoalkylated alkenes in moderate to good yields. Mechanistic studies reveal that an electron donor-acceptor complex formed between O -aryl oximes and DIPEA is presumably involved in this process. The excellent functional group compatibility of this newly designed synthetic protocol allows for cyanoalkylation of structurally varied substrates, which offers an eco-friendly pathway for the assembly of cyanoalkylated alkenes.

Keyphrases

visible light
solar cells
randomized controlled trial
electron transfer
high intensity
single cell
gene expression
dna methylation
case control
electron microscopy