Role of Regulatory T Cells in Skeletal Muscle Regeneration: A Systematic Review.
Jaciara Fernanda Gomes GamaRayza D RomualdoMayara Lopes de AssisLuana M de OliveiraThereza Quírico-SantosLuiz A AlvesJussara Lagrota-CandidoPublished in: Biomolecules (2022)
Muscle injuries are frequent in individuals with genetic myopathies and in athletes. Skeletal muscle regeneration depends on the activation and differentiation of satellite cells present in the basal lamina of muscle fibers. The skeletal muscle environment is critical for repair, metabolic and homeostatic function. Regulatory T cells (Treg) residing within skeletal muscle comprise a distinct and special cell population that modifies the inflammatory environment by secreting cytokines and amphiregulin, an epidermal growth factor receptor (EGFR) ligand that acts directly upon satellite cells, promoting tissue regeneration. This systematic review summarizes the current knowledge regarding the role of Treg in muscle repair and discusses their therapeutic potential in skeletal muscle injuries. A bibliographic search was carried out using the terms Treg and muscle regeneration and repair, covering all articles up to April 2021 indexed in the PubMed and EMBASE databases. The search included only published original research in human and experimental animal models, with further data analysis based on the PICO methodology, following PRISMA definitions and Cochrane guidelines.
Keyphrases
- skeletal muscle
- regulatory t cells
- epidermal growth factor receptor
- stem cells
- insulin resistance
- systematic review
- induced apoptosis
- data analysis
- dendritic cells
- tyrosine kinase
- meta analyses
- cell cycle arrest
- small cell lung cancer
- advanced non small cell lung cancer
- oxidative stress
- single cell
- wound healing
- metabolic syndrome
- gene expression
- immune response
- signaling pathway
- randomized controlled trial
- machine learning
- adipose tissue
- clinical practice
- mesenchymal stem cells
- artificial intelligence
- big data