Anti-Hyperuricemic, Nephroprotective, and Gut Microbiota Regulative Effects of Separated Hydrolysate of α-Lactalbumin on Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice.

Dewei XieYaling ShenErzheng SuLei DuJingli XieDongzhi Wei

Published in: Molecular nutrition & food research (2022)

The anti-hyperuricemia and nephroprotective functions of F5 are mediated by inhibiting hepatic XO activity, ameliorating oxidative stress and inflammation, regulating renal urate transporters, and modulating the gut microbiota in hyperuricemic mice.

Keyphrases

uric acid
oxidative stress
diabetic rats
high fat diet induced
signaling pathway
metabolic syndrome
high glucose
dna damage
ischemia reperfusion injury
induced apoptosis
wild type
insulin resistance