A kind of supramolecular polypeptide nanomedicine (BPC/DOX-ICG) was constructed with an anionic water-soluble [2]biphenyl-extended-pillar[6]arene (AWBpP6), and pyridinium-terminal- and S -nitrosothiol (SNO)-modified polypeptide (PPNC) via host-guest interactions to co-deliver doxorubicin (DOX) and indocyanine green (ICG) for drug resistance reversal. Upon near-infrared (NIR) irradiation, the NO generation could down-regulate the P-glycoprotein (P-gp) expression level to reverse multidrug resistance (MDR). Subsequently, the resulting reverse MDR could sensitize the free DOX and assist photothermal therapy (PTT) to enhance the tumoricidal potential. This supramolecular polypeptide nanomedicine provides an effective strategy for the multimodal synergistic therapies of photothermal therapy, NO generation therapy, and chemotherapy ( i.e. , PTT-NO-CT) to overcome MDR.
Keyphrases
- water soluble
- cancer therapy
- multidrug resistant
- nitric oxide
- fluorescence imaging
- drug delivery
- poor prognosis
- computed tomography
- wastewater treatment
- hydrogen peroxide
- magnetic resonance imaging
- squamous cell carcinoma
- drug release
- locally advanced
- image quality
- radiation induced
- binding protein
- gold nanoparticles
- room temperature
- reduced graphene oxide
- dual energy
- climate change
- cell therapy
- ionic liquid
- smoking cessation