Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers.
Amrita K CheemaYaoxiang LiMary VentimigliaKeith J KowalczykRyan HankinsGaurav BandiEinsley-Marie JanowskiScott GrindrodAlejandro VillagraAnatoly DritschiloPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
To our knowledge, these data are the first report of longitudinal proteomic and metabolomic molecular responses in patients after radiotherapy for cancers. The data supports innate immune activation as a critical clinical response of patients receiving radiotherapy for prostate cancer. Furthermore, we propose that the observed IIR may be generalized to the treatment of other cancer types, potentially informing multidisciplinary therapeutic strategies for cancer treatment.
Keyphrases
- innate immune
- prostate cancer
- early stage
- locally advanced
- end stage renal disease
- radiation induced
- radiation therapy
- electronic health record
- ejection fraction
- newly diagnosed
- radical prostatectomy
- chronic kidney disease
- healthcare
- big data
- papillary thyroid
- peritoneal dialysis
- squamous cell carcinoma
- rectal cancer
- prognostic factors
- childhood cancer
- cross sectional
- replacement therapy