In Vivo Imaging of Local Inflammation: Monitoring LPS-Induced CD80/CD86 Upregulation by PET.

Marco F TaddioClaudia A Castro JaramilloPeter RungeAlain BlancClaudia KellerZeynep TalipMartin BéhéNicholas P van der MeulenCornelia HalinRoger SchibliStefanie D Krämer

Published in: Molecular imaging and biology (2020)

CD80 and CD86 are upregulated in an LPS-induced local inflammation, indicating invasion of activated APCs. 64Cu-NODAGA-abatacept PET allowed following APC activation over time.

Keyphrases

lps induced
inflammatory response
oxidative stress
pet ct
computed tomography
positron emission tomography
rheumatoid arthritis
high resolution
pet imaging
nk cells
cell proliferation
poor prognosis
cell migration
photodynamic therapy
mass spectrometry
disease activity
aqueous solution