Mediation and moderation of genetic risk of obesity through eating behaviours in two UK cohorts.

Shahina BegumEleanor C HintonZoi ToumpakariTimothy M FraylingLaura HoweLaura JohnsonNatalia Lawrence

Published in: International journal of epidemiology (2023)

Genetic predisposition to a higher BMI was partly explained by disinhibition and hunger in two large cohorts. Flexible/rigid restraint may play an important role in moderating the impact of predisposition to higher BMI.

Keyphrases

weight gain
body mass index
weight loss
genome wide
social support
metabolic syndrome
insulin resistance
type diabetes
copy number
physical activity
gene expression
depressive symptoms
stress induced
high fat diet induced