GPNMB methylation: a new marker of potentially carcinogenic colon lesions.

Hassan AshktorabHamed RahiMehdi NouraieBabak ShokraniEdward LeeTahmineh HaydariAdeyinka O LaiyemoPeter SiegelHassan Brim

Published in: BMC cancer (2018)

Our data indicate a high methylation profile leading to a lower GPNMB expression in adenoma and CRC samples. The functional analysis established GPNMB as a potential tumor suppressor gene. As such, GPNMB might be useful as a biomarker of adenomas with high carcinogenic potential.

Keyphrases

genome wide
dna methylation
poor prognosis
polycyclic aromatic hydrocarbons
copy number
big data
long non coding rna
climate change