Mitochondrial mitophagy protection combining rivaroxaban and aspirin in high glucose-exposed human coronary artery endothelial cell. An in vitro study.
Khaoula Zekri-NecharJosé Javier Zamorano-LeónMercedes Cortina-GredillaAna López-de-AndrésRodrigo Jiménez-GarcíaCarlos Navarro-CuellarAntonio López-FarréCarlos Hugo Martínez-MartínezPublished in: Diabetes & vascular disease research (2022)
Under high glucose condition combining Rivaroxaban+ASA increased the mitochondrial content of Pink-1 and Parkin, restored mitochondria membrane potential and reduced ROS and tissue factor expression in HCAEC. It suggests potential effects induced by dual use of Rivaroxaban and ASA on the coronary endothelium subjected to high glucose condition.
Keyphrases
- high glucose
- endothelial cells
- coronary artery
- venous thromboembolism
- atrial fibrillation
- pulmonary embolism
- oxidative stress
- cell death
- pulmonary artery
- poor prognosis
- vascular endothelial growth factor
- reactive oxygen species
- low dose
- coronary artery disease
- nitric oxide
- dna damage
- cardiovascular disease
- heart failure
- cardiovascular events
- type diabetes
- long non coding rna
- endoplasmic reticulum
- climate change
- left ventricular