Activation of brain-derived neurotrophic factor signaling in the basal forebrain reverses acute sleep deprivation-induced fear memory impairments.
Tao MaHao ZhangZhi-Peng XuYan LuQiang FuWei WangGuan-Hua LiYing-Ying WangYi-Tian YangWei-Dong MiPublished in: Brain and behavior (2020)
Acute sleep deprivation induces compensatory increase of BDNF expression in the basal forebrain. Microinjection of BDNF into the basal forebrain mitigates the fear memory impairments caused by sleep deprivation by activating TrkB/PLCγ1 signaling.
Keyphrases
- liver failure
- drug induced
- sleep quality
- physical activity
- respiratory failure
- working memory
- poor prognosis
- aortic dissection
- signaling pathway
- stress induced
- high glucose
- prefrontal cortex
- binding protein
- intensive care unit
- oxidative stress
- diabetic rats
- radiation therapy
- depressive symptoms
- radiation induced
- endothelial cells
- extracorporeal membrane oxygenation
- mechanical ventilation